Trains will not be running between East Croydon and London Victoria as essential rail upgrades take place in the area.
Work is set to take place on 27th and 28th November and over Christmas from 25th December to 3rd January.
During this time Network Rail will continue work on the Victoria resignalling project.
The Victoria resignalling project is a four-year project aimed at upgrading signalling and track at key rail junctions in South London into London Victoria.
As part of the work Pouparts Junction near Clapham is set to be rebuilt with new track and ballast.
The work will also see signal gantries, cable routes and power supply points installed along the lines from Balham to London Victoria.
By conducting the work in “blockades” Network Rail believe they can deliver the benefits of the upgrades to passengers much more quickly.
Network Rail acknowledged the importance of minimising disruption when conducting essential upgrades.
Katie Frost, Sussex Route Director at Network Rail said: “Putting passengers first is at the heart of what we do.
“Blockades are a massive opportunity for us to deliver more efficiently, reduce overall disruption to services and ultimately do more work to improve journeys for our passengers.
“But we won’t forget that that the success of previous extended line closures was in no small part due to our strong focus on passenger and stakeholder management.
“That’s why we’ll work closely with local stakeholders and train operators.
“[We’ll] ensure people who live by the railway, passengers and businesses are fully aware of the impact on their journeys and the alternative travel options available to them.”
Most Southern trains operating on the line will be diverted to London Bridge.
Chris Fowler, Customer Services Director for Southern spoke on the importance of work like this taking place.
Mr Fowler said: “These engineering programmes are essential to give our customers the reliable, on-time services they rightly expect.
“We’re working closely with Network Rail and other transport partners to ensure our customers can get where they need to be when services are affected.”