Essential track and lineside drainage work is set to take place at Water Orton in North Warwickshire and Duddeston in Birmingham.
The improvement work will take place between 19th and 27th February and will include preparation work for HS2.
The alterations form part of the plans to perform long-term improvements to the rail network.
The railway will be closed for the nine-day period whilst the work takes place and will affect services on different routes.
Services between Birmingham New Street, Leicester, Peterborough, Cambridge and Stansted Airport are set to be affected.
The work will also affect services between Cardiff Central and Birmingham New Street to Nottingham.
Line closures will affect services between Scotland, the North East to Birmingham New Street and the South West.
CrossCountry’s long distance trains will make a diversion around the work but this will mean longer journey times.
Patrick Cawley, Director for ‘On Network Works’ for Network Rail and HS2 commented on the work set to take place.
Mr Cawley said: “We’re making great progress on HS2 and a key part of this is making sure it works in harmony with the existing railway.
“While this latest phase of work takes place I’d urge people to please check before they travel with CrossCountry or by using the National Rail Enquiries website or app.”
Richard Morris, Regional Director East Midlands and East Anglia for CrossCountry spoke on the importance of the work.
Mr Morris said: “We are working collaboratively with our industry colleagues at Network Rail, HS2 and West Midlands Trains.
“There will be extended journey times for everyone travelling on the affected routes.
“We are putting extra facilities and staffing in place to ensure passengers can interchange between trains and buses as smoothly as possible.
“I’d urge people to please check before they travel using the National Rail Enquiries website or app.”
Further information on the improvement works can be found by visiting CrossCountry’s dedicated webpage.